Exhibit 21 MERCK & CO., INC. as of 12/31/2002 Each of the subsidiaries set forth below does business under the name stated. Merck Locations and Contact Information The cookies are set in particular in response to your actions and depend on your specific service requests (e.g., pop-up notification choices). [177], In 2007, Merck paid $2.3 billion to settle allegations of offshore tax fraud between 1993 and 2001. Merck KGaA has 21 subsidiaries including Asceneuron, EMD Serono and Intermolecular. [24][25] The combined company has an R&D budget of approximately $1.1 billion and sales of approximately $4.6 billion. Note that this policy may change as the SEC manages SEC.gov to ensure that the website performs efficiently and remains available to all users. [78][79], By 2014, research performed at Merck has led to U.S. FDA approval of 63 new molecular entities. Merck Animal Health is a research-driven company that develops, manufactures and markets a broad range of veterinary medicines and services. By sharing this content, you are consenting to share your data to this social media provider. Sustainability Report 2022 PDF. [58][59] In the year 2018, Merck invested over 1,6 billion in its R&D operations. d) non-standard abbreviations: e) recommended section: Drug Discovery and Translational Medicine In the United States and Canada the subsidiaries of Merck KGaA, Darmstadt, Germany operate under the umbrella brand EMD. We are all accountable for delivering high quality products and services. You are free to decide in the Cookie Settings which categories you would like to permit. [106], In November 2019, the company acquired Calporta, which focused on Parkinsons and Alzheimers treatments. Products of this time included corticoid preparations for example Fortecortin, which is still used today the cold remedy Nasivin or the hormone preparations Gestafortin and Mantova. The settlement was one of the largest pharmaceutical settlements in history. Further information can be found in our Privacy Statement. [179] Merck has been receiving reports since 1998, but never included the risks on the label. [94], In April 2017, Merck Animal Health acquired Valle S.A., a Brazilian animal health product manufacturer. [172] On February 7, 2008, Merck agreed to pay more than $650 million to settle charges that it routinely overbilled Medicaid for its most popular medicines. Weve been fully committed to developing an effective response to the COVID-19 pandemic since it was first recognized. In 2015, Merck acquired SigmaAldrich and combined it with Merck Millipore. About Molnupiravir. We deliver personalized treatments for serious diseases and enable people to achieve their dream of becomingparents. If a user or application submits more than 10 requests per second, further requests from the IP address(es) may be limited for a brief period. The investors' section of Merck provides everything shareholders and potential investors need to know about the company. In 1668, Friedrich Jacob Merck, an apothecary, assumed ownership of the Engel-Apotheke ("Angel Pharmacy") in Darmstadt. To allow for equitable access to all users, SEC reserves the right to limit requests originating from undeclared automated tools. We are a global science and technology company committed to bringing the world together. Try a different search. We strive to identify and meet the most critical needs of patients and customers through continuous innovation across all areas of our business. [63] In 2020, Merck launched partnership with Pechoin in China to develop "high-tech herbal" skincare products. [68], From 2002 through 2005, the Australian affiliate of Merck paid publishing house Elsevier an undisclosed amount to produce eight issues of a medical journal, the Australasian Journal of Bone and Joint Medicine. One whistleblower received a $68 million reward. Find our broad portfolio of 300,000 products, an expansive global footprint and an industry-leading eCommerce . We reserve the right to block IP addresses that submit excessive requests. Merck & Co. traces its origins to its former German parent company Merck Group, which was established by the Merck family in 1668 when Friedrich Jacob Merck purchased a drug store in Darmstadt. Italy/Delaware Johnson & Johnson - Merck Consumer Pharmaceuticals Company1 New Jersey Johnson & JohnsonMSD Consumer Pharmaceuticals Limited1 Great Britain KBI Inc. Delaware KBI Sub Inc. 8) IDENIX PHARMACEUTICALS, INC. IMPERIAL BLUE CORPORATION", "Merck & Co., Inc. Financials SEC Filings SEC Filings Details", "SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. The company assumes no duty to update the information to reflect subsequent developments. [154], On September 23, 2004, Merck received information about results from a clinical trial it was conducting that included findings of increased risk of heart attacks among Vioxx users who had been using the medication for over eighteen months. The launch of the integrated organization was done on 1 June 2020. We reserve the right to block IP addresses that submit excessive requests. Allflex USA, Inc. Delaware. By using this site, you are agreeing to security monitoring and auditing. [61] (Cetuximab was discovered by Imclone Systems, and is marketed in North America by Bristol-Myers Squibb.) The work of our Healthcare business can help to make a difference to millions of lives. MRK - Merck & Co Inc Shareholders - CNNMoney.com . Antibiotics of the carbapenem class play an important role in treatment guidelines for certain hospital-acquired and multi-drug resistant infections. MilliporeSigma, today announced the expansion of its facility in Lenexa, Kansas, USA, adding 98,000 square feet of lab space and production capability to manufacture cell culture media. We do not take professional or ethical shortcuts. Discover how we use science to drive human progress! But dont take it from us see what our people and patients say. Find out how we're supporting the future of our business and the well-being of patients, people and communities around the world. The company was legally known as E. Merck oHG until 1995, when Merck KGaA became the main parent company and the former a holding company. Merck & Co. is not affiliated with or related to Merck KGaA, Darmstadt, Germany, which owns the MERCK trademark in all other countries of the world. Name. Merck KGaA, Darmstadt, Germany, which operates this website, uses the firm name "Merck KGaA, Darmstadt, Germany". [69][70] The CEO of Elsevier's Health Sciences Division, Michael Hansen, admitted that the practice was "unacceptable". Days later the company announced it would acquire IOmet Pharma, with IOmet becoming a wholly owned subsidiary of Merck & Co. Research is at the heart of everything we do. [11], In 2018, the company celebrated their 350th anniversary. [96][97], In October 2017, the company granted the inaugural Merck-AGITG Clinical Research Fellowship in Gastro-Intestinal (GI) Cancer to David Lau, a professional in Melbourne, Australia. The following is an illustration of the company's mergers, acquisitions, spin-offs and historical predecessors: After Wilhelm Adam Sertrner's isolation of morphine from opium in 1805, Merck pioneered (from 1827) the commercial manufacture of morphine for an expanding global market. [158] As of mid-2008, when the plaintiff class had reached the threshold percentage required by Merck to go through with the settlement, plaintiffs had prevailed in only three of the twenty cases that had reached juries, all with relatively small awards. We work hard to bring you the medications and vaccines that help fight some of the most serious health concerns facing all of us. +1 905-919-0299. We offer one of the industry's most innovative portfolios, spanning products for the prevention, treatment and control of disease in all major farm and companion animal species. [167] Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. [83][84], Between 2010 and 2015, the company cut around 36,450 jobs. We follow the science where we can make the greatest difference, now and in the future. RAHWAY, N.J. & SOUTH SAN FRANCISCO, Calif.-- (BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Imago BioSciences, Inc. ("Imago") (Nasdaq: IMGO) today announced that the companies have entered into a definitive agreement under which Merck, through a subsidiary, will acquire Imago for $36.00 per share in c. [127], In July 2021, Robert M. Davis became CEO, succeeding Kenneth Frazier, who became executive chairman. Xinhua Silk Road. Merck & Co. will bring in CM-24, an antibody designed to block the immune checkpoint CEACAM1. Semiconductor Solutions is the largest business unit within Merck's Electronics business sector. These statements are based upon the current beliefs and expectations of the companys management and are subject to significant risks and uncertainties. Select 'Show All Results' link to see additional The cookies are set in particular in response to your actions and depend on your specific service requests (e.g., setting the language). For 130 years, weve focused on not just the next quarter, but the next quarter century. To reflect such fact and to avoid any confusion, certain logos, terms and business description of the publication on this website have been substituted or modified, such as by referring to "Merck KGaA, Darmstadt, Germany" instead of "Merck" standing alone. Lipids: Protecting mRNA so it can protect our body, Our contributions to the fight against Covid-19. Antelliq Finance, Inc. Vaccines are one of the greatest public health success stories and weve been discovering, developing and delivering vaccines to help prevent disease for over 100 years. Worldwide 2023/07/12 . [105], In June 2019, Merck announced it would acquire Tilos Therapeutics for up to $773 million. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. In 2016, the High Court of Justice in the United Kingdom ruled that MSD had breached an agreement with its former parent company and that only Merck of Darmstadt is entitled to use the Merck name in the United Kingdom; the judge also held that MSD's use of "Merck" as part of branding on its global websites were directed to the UK and infringed Merck's trade mark rights in the UK. MilliporeSigma Invests $25 Million to Expand Cell Culture Media Production U.S. The deal includes Merck's Portfolio in Europe and parts of Asia, including China and India. In 1929, H. K. Mulford Company merged with Sharp and Dohme, Inc. and brought vaccine technology, including immunization of cavalry horses in World War I and delivery of a diphtheria antitoxin to Merck & Co. The start-up scene in the United States vs. Germany | Merck KGaA Since the acquisition of Versum and Intermolecular, inc., the company's portfolio in electronic materials was significantly expanded. EX21 Subsidiary List - SEC.gov [31] After the acquisition was completed in 2015, Merck had around 50,000 employees. After the acquisition of Intermolecular, its capabilities allow material combinations to be tested directly in the specific application environment accelerating learning cycles. Thank you for your interest in the U.S. Securities and Exchange Commission. Its corporate website is merckgroup.com in the world excluding U.S. and Canada, displaying normal Merck logo in the header, and emdgroup.com in U.S. and Canada, displaying use of its corporate name, Merck KGaA, Darmstadt, Germany, in the header and additionally displaying a disclaimer about trademark ownership in the footer. [42], In January 2021, MilliporeSigma announced it would acquire AmpTec to expand and enhance the businesses mRNA vaccine capabilities as well as its treatment and diagnostics offerings. In the United States and Canada the subsidiaries of Merck KGaA, Darmstadt, Germany operate under the umbrella brand EMD. We share a love of science and a passion for technology. Discover how curiosity helps us drive human progress! For more than 350 years, weve been pushing the boundaries of whats possible, and well continue to do so in the years to come. On 23 March 2006, Bayer AG made a supported offer for Schering and Merck decided to drop out of the bidding for the company. A settlement with Johnson & Johnson was reached in 2011, in which Merck agreed to pay $500 million. Merck has also modified its equipment to protect the environment, installing a distributed control system that coordinates chemical reactions more efficiently and expedites manufacturing by 50 percent, eliminating the need for the disposal and storage of harmful waste. Merck Benefits from Global Diversification in a Challenging Environment. Accept. Conflict of interest statement: All authors were or are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and shareholders in Merck & Co., Inc., Kenilworth, NJ, USA at the time of their contributions . We aspire to be the premier research-intensive biopharmaceutical company, https://www.merck.com/wp-content/uploads/sites/5/2020/07/Patients-People-Two-People-Hugging-GettyImages-1182734697_HI_102_high-1.jpg, Environmental, Social & Governance (ESG) Report. [34] In October, it was announced that Karl-Ludwig Kley, CEO of Merck since April 2007, would retire in April 2016, and be succeeded by Stefan Oschmann, who has been a member of the executive board since 2011. This website of Merck & Co., Inc., Rahway, N.J., USA (the company) includes forward-looking statements within the meaning of the safe harbor provisions of the U.S. [92][93], In 2017, Merck bought the PARP inhibitor Lynparza from AstraZeneca. United States Department of Health and Human Services, Australasian Journal of Bone and Joint Medicine, New Jersey Business and Industry Association, American College of Obstetricians and Gynecologists, United States Environmental Protection Agency, "Merck & Co., Inc. 2022 Form 10-K Annual Report", "Merck Names 30-Year Company Veteran as CFO", "Merck Appoints Caroline Litchfield Chief Financial Officer", "Merck names Treasurer Caroline Litchfield CFO effective April 1", "The top 10 most profitable pharma companies in 2021", "Pharma 50: The 50 largest pharmaceutical companies in the world", "The top 10 best-selling diabetes drugs of 2013", "Sitagliptin in the treatment of type 2 diabetes: a meta-analysis", "Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies", "AHA: IMPROVE-IT Proves Ezetimibe Benefit", "Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis", "Merck and Johnson & Johnson Reach Agreement on Distribution Rights for Remicade and Simponi", "Merck, Samsung Bioepis Launch Remicade Biosimilar in U.S.", "HIGHLIGHTS OF PRESCRIBING INFORMATION: GARDASIL", "HIGHLIGHTS OF PRESCRIBING INFORMATION: ISENTRESS", "Merck Melanoma Drug Is First PD-1 Inhibitor OK'd by FDA", "HIGHLIGHTS OF PRESCRIBING INFORMATION: Keytruda", "Merck sues Taiwan company over generic antibiotic product", "LABEL: ERTAPENEM- ertapenem sodium injection", "A Pill to Treat Covid-19? We are the company behind the companies, advancing digital living. In addition, Merck was president of the Hessian Chamber of Commerce and Industry as well as performing an advisory function in the Expert Advisory Council for National Health ("Sachverstndigenrat fr Volksgesundheit") of the NSDAP. In recent branding campaigns, the company has referred to itself as "the original Merck" and "the real Merck". The business unit supplies products for every major production step in the wafer processing, including doping, lithography, patterning, deposition, planarization, etching, and cleaning. The company serves customers in biotech, pharma, diagnostics, food safety, academia, and environmental. Explore the latest news from the media center and stay up-to-date with our upcoming events. Merck provides several research grants of up to EUR 350,000 per year for 3 years in various research areas with the . It provides materials, delivery systems, and services for the semiconductor industry. [156][non-primary source needed], About 50,000 people sued Merck, claiming they or their family members had suffered medical problems such as heart attacks or strokes after taking Vioxx. We play an important role in discovering and developing innovative medicines and vaccines to treat and prevent infectious diseases, including HIV and Ebola. In 2015 Merck adopted a uniform brand identity for all its subsidiaries, and the company has stressed its intention to protect the brand of "the real Merck" globally and initiated litigation against its former subsidiary over use of the name. Wilmington, North Carolina, DE 19808, United States of America. 119.65 -1.86% Year-to-Date Quote Profile News Charts Forecasts Financials Shareholders Competitors Insider trading | Institutional ownership Institutional investors hold a majority ownership of MRK. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. [157], Merck has refused to consider compensation for Vioxx victims and their families outside the US. Sorry, no results found. Advancing Digital Living with Electronics. We are dedicated to the highest standard of innovation and scientific excellence. The life science business of Merck KGaA, Darmstadt, Germany, operates as MilliporeSigma in the US and Canada. Our ambition is to leverage science and technology to achieve lasting progress for mankind. Name Country or State of Incorporation Chibret A/S Denmark CM Delaware LLC Delaware Merck Company Profile - Office Locations, Competitors, Revenue - Craft Chemistry, Mode of Action, Mechanisms of Resistance, and Clinical Applications. In oncology, its first marketed product is Erbitux (cetuximab), for which it has marketing rights worldwide, apart from North America. Individual Access. [118] The company also announced it would acquire OncoImmune for $425 million and its phase 3 candidate, CD24Fc, used in the treatment of patients with severe and critical COVID-19. Merck Programs to Help Those in Need - Programs Document - SEC.gov {"analytics":"targeting","share":"targeting"}, {{ search.results.length }} matching results. Other major products by the company include Isentress (raltegravir), an antiretroviral medication used to treat HIV/AIDS that had $857 million in 2020 revenue; Simponi (golimumab), a human monoclonal antibody used as an immunosuppressive drug that had $838 million in 2020 revenue; RotaTeq, a rotavirus vaccine that had $797 million in 2020 revenue; and Lynparza (olaparib), a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults that generated $725 million in 2020 revenue for the company.[1]. Merck ideas are everywhere they can be life-changing, influencing how we tackle major illness, or be integral to the objects we rely on every day. We work to deliver innovations that extend and improve the lives of people with cancer. [184], Media related to Merck & Co., Inc. at Wikimedia Commons. We aspire to be the premier research-intensive biopharmaceutical company. Once the rate of requests has dropped below the threshold for 10 minutes, the user may resume accessing content on SEC.gov. [64], In November 1993, Merck & Co. acquired Medco Containment Services for $6 billion. Select 'Show All Results' link to see additional The same look was also given to the logos of EMD Serono, MilliporeSigma, and EMD Performance Materials (renamed EMD Electronics in March 2021) divisions. [136], Since it was founded in 1957, the Merck Company Foundation has distributed $740 million in overall charitable distributions including more than $480 million to educational and non-profit organizations. We're following the science to tackle some of the world's greatest health threats. [45], In September 2017, Merck said it is considering options for its consumer-health division, including a potential full or partial sale, or strategic partnership. In 2020, the company had 6 blockbuster drugs or products, each with over $1 billion in revenue: Keytruda (pembrolizumab), a humanized antibody used in cancer immunotherapy that had $14.3 billion in 2020 revenue; Januvia (sitagliptin), an anti-diabetic medication used to treat type 2 diabetes that had $5.3 billion in 2020 revenue; Gardasil, an HPV vaccine that had $3.9 billion in 2020 revenue; Varivax, a varicella vaccine used to protect against chickenpox that had $1.9 billion in 2020 revenues; Bridion (Sugammadex), a neuromuscular-blocking drug that had $1.2 billion in 2020 revenue; and Pneumovax 23, a pneumococcal polysaccharide vaccine that had $1.1 billion in 2020 revenue. The core markets for Surface Solutions are automotive coatings, cosmetics, and, to a smaller extent, industrials. Try a different search. Both oHG and KGaA are generic business entity type designations and not used in everyday speech or branding. [170], A fraud investigation by the United States Department of Justice began in 2000 when allegations were brought in two separate lawsuits filed by whistleblowers under the False Claims Act. Physicians Interactive Holdings, Inc. You have accessedhttps://www.emdgroup.com, but for users from your part of the world, we originally designed the following web presencehttps://www.merckgroup.com. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, safety and teamwork of our employees. Wiley (2012). Antelliq Corporation. [108], In January 2020, Merck acquired ArQule, developer of ARQ 531, an oral Bruton's tyrosine kinase (BTK) inhibitor, for $2.7 billion. Merck Animal Health is a research-driven company that develops, manufactures and markets a broad range of veterinary medicines and services. You may review and change your choices at any time. Merck is a vibrant team of specialists in Electronics, Healthcare and Life Science. Merck & Co. closed this facility in July 2010 but remerged in 2011 as Merck Canada. You can search for stories, jobs, events, articles, and more. [10] It is known as MSD ( Merck Sharp and Dohme) outside of North America. [63], In 1991, Merck's Kelco subsidiary was responsible for volatile organic compound (VOC) emission pollution in the San Diego area. Please note that depending on what you select, the full functionality of the website may no longer be available. Merck & Co., Inc. - Subsidiaries of Merck & Co., Inc. - EX-21 - Fintel Learn more about our response to COVID-19. In the United States and Canada, the company trades under the name EMD (an abbreviation of Emanuel Merck, Darmstadt), its legal name here says Merck KGaA, Darmstadt, Germany, and instead of "Merck Group", the "EMD Group" name is used. At MSD, known as Merck & Co., Inc., Rahway, NJ, USA in the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world.