Medically reviewed by Drugs.com. Zonegran is a medicine that contains the active substance zonisamide. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Zonisamide should be discontinued if an alternative etiology for the signs or symptoms cannot be established. To provide you with the most relevant and helpful information, and understand which Drink plenty of fluids while you take Zonisamide Capsules to lower your chance of getting kidney stones. This Medication Guide has been approved by the U.S. Food and Drug Administration. Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial Authors Kishore M Gadde 1 , Mariko F Kopping , H Ryan Wagner 2nd , Gretchen M Yonish , David B Allison , George A Bray Affiliation 1 Obesity Clinical Trials Program, Duke University Medical Center, Durham, NC 27710, USA. In cynomolgus monkeys, administration of zonisamide (10 mg/kg/day or 20 mg/kg/day) to pregnant animals during organogenesis resulted in embryo-fetal deaths at both doses. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. The primary measure of effectiveness was median percent reduction from baseline in partial seizure frequency. It is very important to follow your doctor's dosing instructions exactly. Rats exposed to zonisamide did not exhibit signs of physical dependence of the CNS-depressant type. 1. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. Furthermore, zonisamide suppressed both interictal spikes and the secondarily generalized seizures produced by cortical application of tungstic acid gel in rats or by cortical freezing in cats. Copyright: Merative US L.P. 1973, 2023. All rights reserved. Overdose symptoms may include slow heart rate, feeling light-headed, fainting, and slow or shallow breathing. In a mouse embryo-fetal development study, treatment of pregnant animals with zonisamide (125 mg/kg/day, 250 mg/kg/day or 500 mg/kg/day) during the period of organogenesis resulted in increased incidences of fetal malformations (skeletal and/or craniofacial defects) at all doses tested. Zonisamide capsules USP are available as 25 mg, 50 mg and 100 mg two-piece hard gelatin capsules. It is available as capsules (25, 50 and 100 mg) and orodispersible tablets (25, 50, 100 and 300 mg). Myopia and secondary angle closure glaucoma usually resolve or improve after discontinuation of zonisamide. If you are planning pregnancy, become pregnant, or think you may be pregnant, talk to your doctor right away about the benefits and risks of using this medication during pregnancy. It is usually taken once or twice a day with or without food. The pharmacokinetics of a 300 mg single dose of zonisamide was similar in young (mean age 28 years) and elderly subjects (mean age 69 years). This drug may make you dizzy or drowsy. Instruct patients to take Zonisamide Capsules only as prescribed. Because of the potential for serious adverse reactions in nursing infants from zonisamide, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account the importance of the drug to the mother. In a 30-day study, the GFR returned to baseline within 2 weeks to 3 weeks of drug discontinuation. Examples include other medications to treat seizures (such as phenobarbital, primidone), rifamycins (such as rifabutin), St. John's wort, among others. Uses Warnings Before taking Side effects Dosage Interactions What is zonisamide? Acute myopia and secondary angle closure glaucoma have been reported in patients receiving zonisamide.
Zonegran (Zonisamide): Uses, Dosage, Side Effects The elimination half-life of zonisamide in plasma is approximately 63 hours. Package insert / product label Estimates of the incidence of treatment emergent status epilepticus in zonisamide-treated patients are difficult because a standard definition was not employed. Some manifestations of acute or chronic metabolic acidosis include hyperventilation, nonspecific symptoms such as fatigue and anorexia, or more severe sequelae including cardiac arrhythmias or stupor. In post-marketing experience from Japan, a total of 49 cases of SJS or TEN have been reported, a reporting rate of 46 per million patient-years of exposure. Before taking zonisamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. You may report side effects to FDA at 1-800-FDA-1088. Call your healthcare provider right away if you have any of the symptoms listed above. Rare: Lupus erythematosus.
Zonisamide is a carbonic anhydrase inhibitor. In several clinical studies, zonisamide was associated with a statistically significant 8% mean increase from baseline of serum creatinine and blood urea nitrogen (BUN) compared to essentially no change in the placebo patients. Brand name: Zonegran Drug class: Anticonvulsants, Miscellaneous VA class: CN400 Chemical name: 1,2-Benzisoxazole-3-methanesulfonamide Molecular formula: C 8 H 8 N 2 O 3 S CAS number: 68291-97-4 Medically reviewed by Drugs.com on Oct 19, 2022. Consult your doctor for more details. Zonisamide Capsules may harm your unborn baby. Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself. Zonegran (zonisamide) is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy. There is little experience with doses greater than 600 mg/day. Zonisamide Capsules should be administered once or twice daily, using 25 mg, 50 mg or 100 mg capsules. If it is near the time of the next dose, skip the missed dose. Children younger than 16 years of ageUse and dose must be determined by the doctor. Measurement of baseline and periodic serum bicarbonate during treatment is recommended. No specific antidotes for zonisamide overdosage are available. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Why do cats and dogs use Zonisamide? Zonisamide should not be used in patients with renal failure (estimated GFR < 50 mL/min) as there has been insufficient experience concerning drug dosing and toxicity.
Zonisamide (Zonegran) - Side Effects, Interactions, Uses, Dosage, Warnings Your healthcare prescriber may change your dose. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Get medical help right away if you have any of the following symptoms: bone pain/breakage, rapid breathing, fast/irregular heartbeat, sudden/unexplained tiredness, severe drowsiness/difficulty staying awake.
Buy Zonisamide 100mg Capsules, 56 Capsules - Dock Pharmacy Version: 12.02. There were four suicides in drug-treated patients in the trials and none in placebo-treated patients, but the number is too small to allow any conclusion about drug effect on suicide. : 1-888-304-5011.
Zonisamide Capsules: Package Insert The prescriber should be aware that, because of the long half-life of zonisamide, up to two weeks may be required to achieve steady state levels upon reaching a stable dose or following dosage adjustment. This medicine is available only with your doctor's prescription. Although not approved in pediatric patients, sonographic findings consistent with nephrolithiasis were also detected in 8 % of a subset of zonisamide treated pediatric patients who had at least one renal ultrasound prospectively performed in a clinical development program investigating open-label treatment. Serious allergic reactions that may affect different parts of the body. Zonisamide is the generic name for the brand Zonegran. What are the possible side effects of Zonisamide Capsules? Therefore, if zonisamide is given concomitantly with another carbonic anhydrase inhibitor, the patient should be monitored for the appearance or worsening of metabolic acidosis (see CLINICAL PHARMACOLOGY, Interactions of Zonisamide with Other Carbonic Anhydrase Inhibitors subsection and WARNINGS, Metabolic Acidosis subsection and Hyperammonemia and Encephalopathy subsection). General supportive care is indicated, including frequent monitoring of vital signs and close observation. Canada residents can call a provincial poison control center. Evidence from controlled trials suggests that zonisamide doses of 100-600 mg/day are effective, but there is no suggestion of increasing response above 400 mg/day (see CLINICAL PHARMACOLOGY, Clinical Studies subsection). Stay alert to changes in your mood or symptoms. 6. Zonisamide Capsules taken with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. In the first year of marketing in the U.S., 2 cases were reported, an estimated reporting rate of about 12 cases per 10,000 patient-years of exposure. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness. These side effects can increase the risk of falling. The total daily dose was given as twice a day dosing. It is unknown how zonisamide works to prevent seizures. In vitro studies using human liver microsomes show insignificant (<25%) inhibition of cytochrome P450 isozymes 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, 3A4, 2B6 or 2C8 at zonisamide levels approximately two-fold or greater than clinically relevant unbound serum concentrations. Read and follow the instructions carefully. In the presence of food, the time to maximum concentration is delayed; occurring at 4-6 hours, but food has no effect on the bioavailability of zonisamide. Do not keep outdated medicine or medicine no longer needed. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. It is important to note that early manifestations of hypersensitivity (e.g., fever, lymphadenopathy) may be present even though rash is not evident. 7. Less sweating and increase in your body temperature (fever). Therefore, modification of zonisamide dosing is not necessary when co-administered with known CYP3A4 inhibitors. Zonisamide 100mg Capsules, 56 Capsules 61.25 55.30 This Is A Prescription Product This product can only be bought if you already have a prescription. Adverse Reaction Incidence in Controlled Clinical Trials. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Conditions or therapies that predispose to acidosis (such as renal disease, severe respiratory disorders, status epilepticus, diarrhea, ketogenic diet, or specific drugs) may be additive to the bicarbonate lowering effects of zonisamide. Metabolic acidosis can also increase the risk for hyperammonemia, particularly in the presence of drugs which can cause hyperammonemia. Children may be more sensitive to the side effects of the drug, especially decreased sweating, heat stroke, or metabolic imbalance. Serious eye problems include: sudden decrease in vision with or without eye pain and redness, a blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure glaucoma). This is not a complete list of possible side effects. These reactions can be very serious and can cause death. This medicine is a white brown, oblong, capsule imprinted with "100 mg" and "IG228". The primary treatment to reverse symptoms is discontinuation of zonisamide as rapidly as possible, according to the judgment of the treating physician. Take Zonisamide Capsules with or without food. Zonegran may cause serious side effects, including: Serious skin rash that can cause death. If you notice other effects not listed above, contact your doctor or pharmacist. An in vitro study showed that zonisamide is a weak inhibitor of P-gp (MDR1) with an IC50 of 267 mol/L. In animals, zonisamide was effective against tonic extension seizures induced by maximal electroshock but ineffective against clonic seizures induced by subcutaneous pentylenetetrazol. A reduction in growth rate may eventually decrease the maximal height achieved. It can be increased to 300 mg/day and 400 mg/day, with the dose stable for at least two weeks to achieve steady state at each level. This medicine comes with a Medication Guide. Zonisamide Capsules are contraindicated in patients who have demonstrated hypersensitivity to sulfonamides or zonisamide. If signs of hypersensitivity or other serious reactions occur, discontinue zonisamide immediately. A poison control center should be contacted for information on the management of zonisamide overdosage.
Zonisamide 100 mg |Zonegran 100 mg Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity may be at an increased risk for hyperammonemia with or without encephalopathy and this risk may be increased by zonisamide use. The secondary measure was proportion of patients achieving a 50% or greater seizure reduction from baseline (responders). The safety and effectiveness of zonisamide in children under age 16 have not been established.
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