They may suggest changing your medicine so that the sexual problems improve or stop. Do not suddenly stop taking this medicine without checking first with your doctor. https://doi.org/10.1053/jhep.2001.27447, Holtmann M, Kopf D, Mayer M et al (2003) Risperidone-associated steatohepatitis and excessive weight-gain. 1996). 3). Toxicol Sci 103:335345. Ann NY Acad Sci 899:191208. Eur J Pharm Sci 59:2030. J Psychiatr Pr 20:301307. Dig Dis Sci 48:939944. Note that this list is not all-inclusive and includes only common medications that may interact with quetiapine. 2014) (Fig. https://doi.org/10.1124/dmd.113.056267, Yuan W, Williams B (2012) Acute hepatic failure involving duloxetine hydrochloride. https://doi.org/10.1176/appi.neuropsych.11040083, Zanger UM, Schwab M (2013) Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. How it works Quetiapine may be used to reduce psychotic, manic, or depressive episodes. Drug Metab Rev 44:3487. Todorovi Vukoti, N., orevi, J., Peji, S. et al. Blood and urine tests may be needed to check for unwanted effects. Swallow extended-release tablets whole, do not crush or chew. GOV.UK has more information on the law on drugs and driving. Ask your pharmacist to recommend a painkiller. The results of some tests (eg, urine drug screens) may be affected by this medicine. https://doi.org/10.3389/fpsyt.2019.00093, Liu Z, Cui C, Xu P et al (2017) Curcumin activates AMPK pathway and regulates lipid metabolism in rats following prolonged clozapine exposure. Quetiapine-induced hepatocellular damage. For non-prescription products, read the label or package ingredients carefully. Google Scholar, Ahmad J, Odin JA (2017) Epidemiology and genetic risk factors of drug hepatotoxicity. adjusted in steps of 50 mg daily, usual dose 400-800 mg once daily; maximum . The antipsychotic medicine you're prescribed will depend on your condition and how severe it is, any other conditions you have, and how well the medicine works for you. https://doi.org/10.1159/000494573, Chen T, Tzeng N, Tai Y (2019) Amitriptyline-Induced acute kidney injury and acute hepatitis: a case report. Annu Rev Med 64:393406. This effect was observed in cultured human liver cells (Raeder et al. 3). Is Seroquel Habit-Forming? If you feel dizzy when you stand up, try standing up slowly and hold onto something to steady your balance until the dizziness has passed. Your doctor may adjust your dose as needed. However, the reactive metabolites have not been identified yet, although it is known that sertraline is extensively metabolized by hepatic CYP450 (Fartoux-Heymann et al. Physiol Res 57:801811, PubMed 2016). Free Radic Biol Med 47:213218. by 50-150 mg/day up to 300-400 mg/day PO divided bid-tid by day 4, then may adjust dose by 50-100 mg/day no more frequently than q2 days prn; Max: 800 mg/day . Hepatology 48:770781. A study of Morln-Coarasa et al. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. However, if your doctor tells you to take it a certain way, take it as directed. https://doi.org/10.3390/toxins5112227, Mutairi FA, Dwivedi G, Al Ameel T (2012) Fulminant hepatic failure in association with quetiapine: a case report. effects associated with the use of quetiapine, an atypical antipsychotic. Pharmacopsychiatry 29:7980. Psychopharmacology 233:39473952. As a result, FFAs increasingly undergo esterification into triglycerides that accumulate in hepatocytes as benign large lipid droplets (Bessone et al. Seek urgent medical advice if you develop a high temperature, muscle rigidity, or confusion. Effects of Seroquel on the Liver Seroquel use may cause elevated liver enzymes. Naunyn Schmiedebergs Arch Pharmacol 383:423436. Curr Drug Metab 9:410418, Van Harten J (1995) Overview of the pharmacokinetics of fluvoxamine. When used as maintenance therapy for manic episodes in bipolar 1 disorder, it is best used in addition to lithium or Divalproex. It's your responsibility to decide if it's safe to drive. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Biochem Mol Biol Educ 34:6674. 2019a, b) (Fig. https://doi.org/10.1016/S1734-1140(11)70510-2, Isaacson RH, Beier JI, Kh N et al (2020) ScienceDirect Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane. Neurotox Res 30:173184. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Google Scholar, Bjornsson E, Kalaitzakis E, Olsson R (2007) The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. https://doi.org/10.1056/NEJMra052270, Neumann H, Csepregi A, Evert M, Malfertheiner P (2008) Drug-induced liver disease related to citalopram. (2016) aimed to investigate the development of fatty liver during the first 3years of SGA treatment (aripiprazole, risperidone, quetiapine, and ziprasidone) in 191 non-affective psychosis patients. or if there are treatment-emergent signs or symptoms of hepatic
2012). https://doi.org/10.1345/aph.1G339, Pillinger T, Mccutcheon RA, Vano L et al (2020) Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. https://doi.org/10.1186/s12906-015-0627-2, Ye H, Nelson L, Gmez Del Moral M et al (2018) Dissecting the molecular pathophysiology of drug-induced liver injury. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. https://doi.org/10.2174/1570159X11666131120231448, Yajima D, Motani H, Hayakawa M et al (2009) The relationship between cell membrane damage and lipid peroxidation under the condition of hypoxia-reoxygenation: analysis of the mechanism using antioxidants and electron transport inhibitors. J Clin Pathol. Steatosis occurs in two primary forms, macrovesicular and microvesicular. https://doi.org/10.1111/j.2040-1124.2011.00111.x, Mauri MC, Fiorentini A, Paletta S, Altamura AC (2014) Pharmacokinetics of antidepressants in patients with hepatic impairment. Clin Pharmacokinet 53:10691081. Lancet 376:190201. Liver Int 40:17701780. 2019). May cause a discontinuation syndrome if abruptly stopped; symptoms include nausea, insomnia, headache, diarrhea, vomiting, irritability, and dizziness. Interestingly, the other two TCAs, amineptine and tianeptine, were shown to cause mild hepatic steatosis due to heptanoic chain attached to a tricyclic moiety. In addition, acute hepatitis was described in a patient 8weeks after beginning tianeptine administration (Bricquir et al. Do not double doses. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. Liver Int 26:912919. Arch Toxicol. When Is Seroquel Prescribed? J Hepatol 21:771773. Personalized medicine should be the preferred approach whenever possible and mandatory for risk groups of patients. Some people cannot concentrate properly while they're taking it. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Int J Clin Pract 59:861862. If you notice any other effects, check with your healthcare professional. What Does Quetiapine Do to the Brain? There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Thus, scarce data regarding liver inflammatory changes under ADs are mostly related to SSRI drugs. In this respect, therapy must be carefully planned, tailored, and monitored, not just in terms of the effect on a psychiatric disorder of patient, but hepatic homeostasis, as well. All these studies accumulated evidence that olanzapine has multifaceted effects on hepatic lipid metabolism, including (1) increasing de novo lipogenesis; (2) decreasing lipoprotein internalization and cholesterol clearance; and (3) reducing VLDL secretion through down-regulation of VLDL secretion-related proteins, including apoB and apoE; which all together result with lipid accumulation in the liver (Chen et al. Cholestatic hepatitis involving mixed portal inflammatory infiltrates along with eosinophils was also described in a patient taking venlafaxine (Stadlmann et al. Experts aren't exactly sure how quetiapine works but research suggests it binds to receptors in the brain stimulated by chemicals (neurotransmitters) such as dopamine, histamine, and serotonin. Quetiapine and Hepatic Reactions. CNS Spectr 17:210. https://doi.org/10.1007/s00213-008-1370-x, Filipovi D, Mandi LM, Kanazir D, Pajovi SB (2010) Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver. Both cases were accompanied by obesity and abnormal serum levels of the liver enzymes (Kumra et al. https://doi.org/10.1016/0006-2952(89)90580-7, Fuller CM, Yassinger S, Donlon P et al (1977) Haloperidol induced liver disease. It is an atypical antipsychotic agent proven to be effective for the management of negative and positive symptoms of. of hepatobiliary reactions with the use of quetiapine. However, elderly patients are more likely to have dementia or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving quetiapine. https://doi.org/10.3390/ijms161125942, Li Y, Su R, Xu S et al (2017) Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Australas Psychiatry 27:535. https://doi.org/10.1177/1039856219848824, Telles-Correia D, Barbosa A, Cortez-Pinto H et al (2017) Psychotropic drugs and liver disease: a critical review of pharmacokinetics and liver toxicity. Try to exercise more regularly, for example, by going for a daily walk or run. Ask your doctor if you have any questions. https://doi.org/10.1111/j.1365-2036.2007.03330.x, Bleakley S (2016) Antidepressant drug interactions: Evidence and clinical significance. BMC Med 14:111. World J Gastroenterol 12:74137420. You can report any suspected side effect using the Yellow Card safety scheme. https://doi.org/10.1016/j.taap.2015.03.006, de Oliveira MR (2016) Fluoxetine and the mitochondria: A review of the toxicological aspects. Br J Clin Pharmacol 34:262265. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, changes in patterns and rhythms of speech, increased blinking or spasms of the eyelid, rapid or worm-like movements of the tongue, shakiness in the legs, arms, hands, or feet, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, arms, hands, feet, or lower legs, trembling and shaking of the hands and fingers, trouble with breathing, speaking, or swallowing, uncontrolled movements of the arms and legs, uncontrolled twisting movements of the neck, trunk, arms, or legs, Aching or discomfort in the lower legs or sensation of crawling in the legs, blistering, peeling, or loosening of the skin, muscle cramps, spasms, stiffness, or twitching, painful or prolonged erection of the penis, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, unusual bleeding or bruising unusual drowsiness, dullness, or feeling of sluggishness. Mol Cell Endocrinol 424:1222. https://doi.org/10.1111/apt.12925, Mullock BM, Hall DE, Shaw LJ, Hinton RH (1983) Immune responses to chlorpromazine in rats. Arch Toxicol 95, 767789 (2021). https://doi.org/10.1016/j.transproceed.2009.09.022, Djurasevic S, Todorovic Z, Pavlovic S, Pejic S (2019) Cadmium and fullerenes in liver diseases. if signs or symptoms of hepatic impairment develop during treatment. If you're in any doubt, do not drive. Drug-induced liver injury is a common cause of liver damage and the most frequent reason for withdrawal of a drug in the United States. %>, New Zealand Medicines and Medical
Do not take other medicines unless they have been discussed with your doctor. Can J Gastroenterol 23:376378. Chronic exposure to sertraline was shown to down-regulate expression of drug- and arachidonic acid-metabolizing enzymes in hepatic tissue, indicating that patients using this drug may be at risk of hepatotoxicity with reduced capacity to metabolize drugs and fatty acids (Almansour et al. Quetiapine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. 1989; Pessayre et al. Persistent and excessive endoplasmic reticulum stress response (ERSR) broke the alleviating effect of the unfolded protein response (UPR) on stress, facilitating the progress . 2006; Vuppalanchi et al. PubMedGoogle Scholar. Tylenol, weight-loss supplements, and green tea extract have all been linked to these types of issues. sharing sensitive information, make sure youre on a federal You'll usually start on a low dose. Last updated on Jan 1, 2022. Here is also important to address the question concerning the applicability of rodent models for understanding hepatic pro-inflammatory effects of drugs. https://doi.org/10.1016/j.toxlet.2020.02.007, Kolios G, Valatas V, Kouroumalis E (2006) Role of Kupffer cells in the pathogenesis of liver disease. 1984) were also demonstrated. This AP dysregulated glucose and lipid metabolism, caused mild glucose intolerance, increased body weight, and caused hepatic steatosis in the mouse model after only 4weeks. QP-loaded albumin NPs were prepared by the . Summarizing hepatic inflammatory pathways demonstrated for listed antidepressants (ADs) and antipsychotics (APs). The viruses that cause liver damage can be spread through blood or semen, contaminated food or water, or close contact with a person who is infected. Speak to your doctor about how drug interactions should be managed. An official website of the United States government. Finally, patients should be informed that ADs and APs can be associated with liver damage, even liver failure, and encouraged to refer to a primary care physician or psychiatrist if any DILI-related symptoms emerge. Quetiapine is used alone or together with other medicines to treat bipolar disorder (depressive and manic episodes) and schizophrenia. Environ Toxicol Pharmacol 61:107115. Only one-sixth of the quetiapine dose is needed when taken with drugs that are CYP3A4 inhibitors (for example, ketoconazole, ritonavir, or nefazodone). PubMed Visit Yellow Card for further information. This is the second reported case of quetiapine-induced liver injury in the published literature. https://doi.org/10.4306/pi.2010.7.3.228, Park BK, Laverty H, Srivastava A et al (2011) Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. https://doi.org/10.1093/toxsci/kfs100, Li S, Tan H-Y, Wang N et al (2015) The role of oxidative stress and antioxidants in liver diseases. The use of antipsychotics in elderly patients with dementia has been associated with an increased risk of death, mostly due to cardiovascular or infectious causes. Nevena Todorovi Vukoti. Brain Behav Immun 89:594600. https://doi.org/10.1038/sj.npp.1301070, Raeder MB, Fern J, Vik-Mo AO, Steen VM (2006) SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? https://doi.org/10.1159/000450878, Castanheira L, Fernandes E, Levy P, Coentre R (2019) Aripiprazole-induced hepatitis: a case report. Am J Psychiatry 153:580. https://doi.org/10.1176/ajp.153.4.580a, Friedrich ME, Akimova E, Huf W et al (2016) Drug-induced liver injury during antidepressant treatment: results of AMSP, a drug surveillance program. 2016). You might vomit or have an upset stomach. The risk of very serious side effects is extremely low. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. https://doi.org/10.4081/mi.2019.8113, Grady MM, Stahl SM (2012) Practical guide for prescribing MAOIs: debunking myths and removing barriers. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. government site. All rights reserved. Your doctor may need to check your weight on a regular basis while you are using this medicine. Trouble swallowingUse with caution. https://doi.org/10.1016/j.redox.2016.10.001, Duda W, Curzytek K, Kubera M et al (2016) the effect of chronic mild stress and imipramine on the markers of oxidative stress and antioxidant system in rat liver. https://doi.org/10.1002/hep.1840200610, Morgan MJ, Liu Z (2011) Crosstalk of reactive oxygen species and NF-B signaling. Int J Pharm Pharm Sci 8:2832. https://doi.org/10.1093/ijnp/pyv126, Fromenty B, Freneaux E, Labbe G et al (1989) Tianeptine, a new tricyclic antidepressant metabolized by -oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Pharmacol Ther 138:103141. Hepatology 34:548556. Check your blood sugar closely and talk with your doctor if you have any questions. Also, a special attention should be paid when implementing therapy combining SGA and AD, which is often the case in treatment-resistant depressive patients. Quetiapine calms and sedates and is used to help reduce the incidence of psychotic thoughts in people with schizophrenia. Try to stick to the national guidelines of no more than 14 units a week. https://doi.org/10.1093/jat/20.6.502, Li Y, Couch L, Higuchi M et al (2012) Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Common medications that may interact with quetiapine include: Avoid drinking alcohol or taking illegal or recreational drugs while taking quetiapine. Page last reviewed: 6 July 2022 However, few studies described the pro-inflammatory effects of fluoxetine in rat liver. Appropriate studies have not been performed on the relationship of age to the effects of quetiapine extended-release tablets to treat major depressive disorder in the pediatric population. Some content may no
1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Front Neurosci. Neuropharmacology 62:784796. You may report side effects to the FDA at 1-800-FDA-1088. Your doctor may adjust your dose as needed. https://doi.org/10.1155/2016/1247191, Yu K, Geng X, Chen M et al (2014) High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Biochim Biophys Acta Mol Basis Dis 1842:23292343. Most antipsychotic medicines like quetiapine can sometimes cause sexual problems, but some are more likely to cause these problems than others. These common side effects of quetiapine may happen in more than 1 in 10 people. Gradual withdrawal is advised. https://doi.org/10.1097/JCP.0000000000000749, De Hert M, Detraux J, Van Winkel R et al (2012) Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. However, quetiapine can make you feel hungrier and put on weight. The amount of medicine that you take depends on the strength of the medicine. Speak to your doctor if you have any problems with your movement. If you have diabetes, the results of your urine or blood sugar tests may change. Severe cases of hepatitis, even fatal in a small minority, have been observed. Although fulminant and irreversible liver injury due to ADs or APs is a rare event, hepatotoxicity of these drugs should be recognized and carefully considered. Click here for an email preview. (2013) reported that olanzapine- and aripiprazole-treated rats developed steatosis in the liver, whereby more prominent changes were caused by olanzapine. https://doi.org/10.1111/jcpt.12760, Article Gastroenterology 135:1924-1934.e4. 2008; Slim et al. Side Effects Drug information provided by: Merative, Micromedex Along with its needed effects, a medicine may cause some unwanted effects. https://doi.org/10.1111/j.1749-6632.2000.tb06187.x, tefan M, Kiss B, Gutleb A, Loghin F (2020) Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects. https://doi.org/10.1023/A:1023007831047, Pessayre D, Fromenty B, Berson A et al (2012) Central role of mitochondria in drug-induced liver injury. A pint of lager or beer is usually 2 to 3 units of alcohol. Medically reviewed by Carmen Fookes, BPharm. Can I drink alcohol while taking quetiapine? Next review due: 6 July 2025, Putting on weight or changes to your appetite, Swollen breasts, pain in your breasts or leaking breast milk, Visit Yellow Card for further information, Taking quetiapine with other medicines and herbal supplements, twitching or jerking movements that you cannot control in your face, tongue, or other parts of your body, infections, such as cold or flu symptoms, high temperature, or ear, eye, bladder or chest infections, swelling, pain and redness in your leg this may be a sign of blood clots, you have weakness on one side of your face or body, trouble speaking or thinking, loss of balance or blurred eyesight these can be signs of a stroke, you have a painful erection that lasts more than 2 hours (priapism) this may happen even when you are not having sex, you have chest pain or difficulty breathing these may be signs of a blood clot in your lungs, you have a high temperature, muscle stiffness, sweating, anxiety or excess saliva these may be signs of a disorder called neuroleptic malignant syndrome, your lips, mouth, throat or tongue suddenly become swollen, you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air), your throat feels tight or you're struggling to swallow, your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet), you suddenly become very confused, drowsy or dizzy, a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face). https://doi.org/10.4065/74.7.692, Carvalhana S, Oliveira A, Ferreira P et al (2016) Acute liver failure due to trazodone and diazepam. Hepatitis, inflammatory liver disease, was reported in patients treated with various TCA drugs. https://doi.org/10.1016/0002-9343(86)90826-0, Breuer RI (1965) Chlorpromazine hepatotoxicity manifested by a selective and sustained rise of serum alkaline phosphatase activity - Report of a case. All ADs and APs listed in this review have the potential to cause hepatotoxicity, even at therapeutic doses. Experts aren't sure exactly how Trintellix (vortioxetine) works but it is thought to increase levels of a neurotransmitter, called serotonin in the brain. https://doi.org/10.1097/01.MAT.0000132552.58214.00, Bergstrom R, Beasley C, Levy N et al (1993) The effects of renal and hepatic disease on the pharmacokinetics, renal tolerance, and risk-benefit profile of fluoxetine. Initially 25 mg twice daily, adjusted according to response. https://doi.org/10.1002/cbf.1578, Yang Q, Yang F, Tang X et al (2015) Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang. . Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Regular exercise will also help to keep your weight stable. Epub 2021 Jan 5. https://doi.org/10.1055/s-2002-31515, Azirak S, Bilgic S, Korkmaz DT et al (2019) The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression. The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications. https://doi.org/10.1016/j.ejps.2015.10.010, Urichuk L, Prior TI, Dursun S, Baker G (2008) Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. https://doi.org/10.1016/j.biopha.2018.04.109, Herrera B, Fernndez M, lvarez AM et al (2001) Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome c release in apoptosis induced by transforming growth factor in rat fetal hepatocytes. Curiously, fatal hepatitis was reported in a patient treated with sertraline (Fartoux-Heymann et al. Int J Neuropsychopharmacol 19:19. Acta Pharmacol Sin 39:14631472. https://doi.org/10.1371/journal.pone.0114085, Shanks N, Greek R, Greek J (2009) Are animal models predictive for humans? Seek urgent medical advice if these symptoms develop. https://doi.org/10.1080/15376516.2016.1204641, El Hajj I, Sharara AI, Rockey DC (2004) Subfulminant liver failure associated with quetiapine. Advertising revenue supports our not-for-profit mission. Trouble urinating, or history ofMay increase risk for more serious side effects. Data sources include IBM Watson Micromedex (updated 3 July 2023), Cerner Multum (updated 10 July 2023), ASHP (updated 10 July 2023) and others. Be careful when using a regular toothbrush, dental floss, or toothpick. It is often associated with chronic lipid peroxidation, development of steatohepatitis, liver insufficiency, and encephalopathy, and can be life-threatening when extensive or long-lasting (Amacher and Chalasani 2014). CAS Nat Rev Endocrinol 8:114126. Sedation, low blood pressure, and weight gain are common side effects. https://doi.org/10.1007/BF02893045, Han D, Hanawa N, Saberi B, Kaplowitz N (2006) Mechanisms of liver injury. This interspecies variability in protein expression contributes to the debatable predictive value of animal models in toxicity of drugs, including their hepatic pro-inflammatory effects. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. 2023 Jan 25;14:1097284. doi: 10.3389/fphar.2023.1097284. Read and follow the instructions carefully. enzyme levels, particularly aspartate aminotransferase (AST), alanine aminotransferase
Talk to your doctor if you feel excessively thirsty or are urinating more than normal. Folia Biol 59:174180, Solomons K, Gooch S, Wong A (2005) Toxicity with selective serotonin reuptake inhibitors. Publications
If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: This medicine may cause tardive dyskinesia (a movement disorder).